To test whether loss of MGRN1 function can contribute to the pathogenesis of prion disease, male and female mice homozygous for the Mgrn1md−nc null mutation and heterozygous controls were inoculated with RML prions and carefully monitored for signs of illness and neurological symptoms associated with prion infection (one or more of the following: weakness in rear, paresis, wobble in rear, abnormal gait, abnormal posture, generalized tremor, tail rigidity, poor righting reflex). Here, MGRN1 is linked to prion disease.