Most ICL patients (14/15) also had CD8+ T cell depletion, as indicated by a median CD8+ T cell count of 103/mm3 [15–1134] and by a relatively preserved CD4/CD8 ratio (median ratio: 1.28 [0.03–5.6]). The gene discussed is CD8A; the disease is idiopathic CD4 lymphocytopenia.