Importantly, decreased IL-2 responses in Memc correlated with decreased CD4+ T cell counts in the blood of ICL patients (RICL = 0.63, p<0.05, Fig. 4G), suggesting that defective IL-2 responses may contribute to the loss of CD4+ T cell homeostasis. The gene discussed is IL2; the disease is idiopathic CD4 lymphocytopenia.