Furthermoe, the levels of several NF-κB target genes, TNF-α, IL-6, CCND1, MYC, BcL-XL and MMP-9, were upregulated in Bmi-1-overexpressing, but downregulated in Bmi-1-silenced glioma cells (Figure 5B). Here, MMP9 is linked to central nervous system cancer.