B-cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1) is a member of the polycomb gene family and has been found upregulated in a variety of human cancer types including acute myeloid leukemia and breast, colon, lung, ovarian and nasopharyngeal cancers, suggesting a potential role of Bmi-1 as an oncogene [14]–[19]. The gene discussed is BMI1; the disease is cancer.