Thus, in combination with c-Abl/Arg inhibitors, doxorubicin may be effective in cancers not previously treated with this agent (e.g. melanoma), and c-Abl/Arg inhibitors may decrease doxorubicin toxicity in cancers where the drug currently is used (e.g. breast cancer) by decreasing the doxorubicin dose required for effective treatment. This evidence concerns the gene ABL1 and cancer.