VEGFA and psoriasis: Based on the findings that proliferation of keratinocytes could be promoted via VEGF/VEGFRs pathway [26], [27], and that treatment with a VEGFR tyrosine kinase inhibitor could inhibit chronic and acute skin inflammation [57], we hypothesized that the overexpressed VEGFRs in psoriatic epidermis might be involved in the pathological process of psoriasis.