TRPV5 and Hypercalciuria: The extent of hypercalciuria in Trpv5682P/+ mice (∼10-fold above wild-type) was similar to that reported for Trpv5-/- mice (∼6-fold above wild-type)[25]_ENREF_19, and in Trpv5682P/682P mice, this was significantly higher than both Trpv5682P/+ and Trpv5-/- (∼20-fold above wild-type), despite TRPV5-S682P causing only an ∼40% decrease in basal calcium influx in HEK293 cells (Table 1, Figure 2E–F).