Thus, this study was aimed at assessing whether: i) the reported oxidative stress in DM involves also VWF, changing its levels and multimeric structure; ii) the proteolytic processing of VWF by ADAMTS-13 is altered by changes of either levels or function of ADAMTS-13; iii) the presence of oxidized VWF is associated with micro- and macro-angiopathic disorders in a set of both type 1 and type 2 diabetic patients. Here, VWF is linked to diabetes mellitus.