The formation and consolidation of memory require the participation of some central molecular devices such as glutamate receptors and synaptic scaffolding proteins [43], [44].Previous study had shown that zinc deficiency might reduce NMDA receptor expression in rat brains [39], Adlard et al. also observed significantly decreased AMPA, NMDA-NR2A and NR2B receptors and scaffolding PSD-95 levels in old ZnT3KO mice [45]. The gene discussed is DLG4; the disease is Zinc deficiency.