PTX3 and rheumatoid arthritis: However, the possibility of such a role is strengthened by the fact that PTX3 secretion from RA monocytes was induced by an immunosuppressant cytokine (IL-10), but not by pro-inflammatory cytokines (IFN-γ and IL-1β not shown; the effect of IFN-γ on PTX3 production was the same as that described previously in human peripheral blood mononuclear cells in ref. [3]).