Additionally, recent biochemical studies support a role of transcriptional regulation by TACC1 (highly expressed in MS placentas), and its interaction with nuclear receptors devoid of their respective ligands (aporeceptors) including AR, RXRα, RARα, PPARγ, ERα, GR, TRα1 and TRα2 [85]. The gene discussed is PPARG; the disease is myeloid sarcoma.