[5], [8], [34] This acute-phase reactive protein is produced primarily in the liver, and its expression is up-regulated by pro-inflammatory cytokines such as interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor (TNF). [35] CRP level is elevated in chronic inflammatory environments, which may lead to excessive cell proliferation and subsequent accumulation of DNA damage. The host immune system responds to tumor growth via elevated levels of inflammatory cytokines, which may further increase CRP levels. [36], [37]. Here, TNF is linked to neoplasm.