DAPK1 and B-cell chronic lymphocytic leukemia: Furthermore, a prospective investigation of DAPK1 ASE in healthy individuals with monoclonal B cell lymphocytosis (MBL), a potential precursor of CLL that shows a prevalence of up to 3.5% in the entire population, would allow for a more accurate assessment of the predisposing character of DAPK1 ASE [34].