Consequently, 17 out of 120 CLL samples (14.2%) were identified to harbor allele-specific mRNA expression imbalance for DAPK1. Complementing this finding, we used an alternative procedure based on the α-outlier region approach at an α-level of 5% [30] to define ASE-positive patient samples stringently assuming an underlying normal distribution. Here, DAPK1 is linked to B-cell chronic lymphocytic leukemia.