We analyzed whole PBMCs from 120 CLL patients and 63 healthy controls for ASE of DAPK1. As DAPK1 has been shown to be consistently silenced in B cells of the CLL clone [8] and to be strongly expressed from monocytes and natural killer (NK) cells, the observed allelic expression differences can be attributed to germline in both, healthy controls and CLL patients. Here, DAPK1 is linked to B-cell chronic lymphocytic leukemia.