Collectively, the increased leptin levels in airway allergic inflammatory response, subdued leptin receptor on allergic asthmatic children compared to healthy controls, and leptin-induced neutrophil survival suggest that the effect of leptin/leptin R in this heterogeneous disease process (asthma) is complicated and may partly be responsible for the neutrophilic inflammation observed in some of the asthma cases [28], [46]. This evidence concerns the gene LEP and asthma.