To determine if a new subtyping-scheme of EPCs would give further insight into the dynamic modulation of circulating EPC numbers during cerebrovascular disease progression, we next tested expression of the dual endothelin1/VEGFsp receptor (DEspR, formerly called Dear) on cd45- [cd34+/kdr+]EPCs by 4-label LSRII-FACS analysis. This evidence concerns the gene FBXW7-AS1 and cerebrovascular disorder.