To further and systematically evaluate associations between skin rash and the efficacy of EGFR-TKIs and the prognosis of patients with non-small cell lung cancer, we performed a systematic review and meta-analysis of 33 studies to evaluate the role of skin rash in predicting the efficacy and PFS and OS of patients with non-small lung cancer treated with EGFR-TKIs. This evidence concerns the gene EGFR and non-small cell lung carcinoma.