It is interesting to note that the stimulation of the Burkitt lymphoma cell line with the TLR-9 agonist ODN 2395 at a concentration (1 μM) and for a period of time (15 to 24 hrs) previously reported to stimulate a TLR-9-dependent response (TNF and/or IL-6 production) [52], [53], also failed to trigger a type-I IFN production (Figure 11B). The gene discussed is TNF; the disease is Burkitt lymphoma.