Before assessing whether human transformed/tumor cells produce type-I IFNs and develop an antiviral response upon MVMp or H-1PV infections, we first characterized the ability of some lines known to be more (NB324K and HEK293T) or less (HEK293 and Hela) permissive to these viruses, to produce and release IFN-β upon their exposure to classical activators of antiviral defense mechanisms like Poly(I:C), a synthetic dsRNA, (pI:C) [44], or the avian paramyxovirus Newcastle Disease Virus (NDV, Ulster strain) [39], [45], [46]. Here, IFNB1 is linked to neoplasm.