Indeed, we show that upon rodent parvovirus infection, human peripheral blood mononuclear cells (hPBMCs) produce and release both IFN-α and -β molecules and show hallmarks of activation of an antiviral response whereas human transformed/tumor cells, being or not of immune origin, never showed such effects upon MVMp- or H-1PV infection. This evidence concerns the gene IFNA2 and neoplasm.