It could also be proposed that EBV factors impair the TLR-9-dependent IFN production in the Burkitt lymphoma cells as described in several studies [70], [71], or that the efficient multiplication observed for both rodent parvoviruses in the B cell lines [54] allows the development of an evasion mechanism inhibiting at a very early step (before NF-κB activation) the TLR-9 pathway. The gene discussed is NFKB1; the disease is Burkitt lymphoma.