Further statistical analyses revealed that proteolyzed IGFBP-3 positively correlates with adiposity parameters such as waist circumference (r = 0.608, P<0.001), BMI (r = 0.4651, P<0.001), fasting insulin (r = 0.307, P = 0.001), and insulin resistance index (HOMA-IR) (r = 0.313, P<0.001) in overweight and obese population (Figure 1C), suggesting that predisposition to insulin resistance and other consequences of increased visceral fat can occur even in overweight individuals and not necessarily only in obese population. This evidence concerns the gene IGFBP3 and Insulin resistance.