The endocrine paradigm suggests that visceral fat in obesity, consisting primarily of adipocytes, secretes various pro-inflammatory and pro-atherogenic adipokines such as TNF-α, C-reactive protein (CRP) [3], IL-6 and others [4] creating a state of local inflammation further resulting in chronic systemic inflammation and accelerating the events leading to metabolic disorders. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.