Surprisingly, chromatin remodeling did not alter the expression of any of the “disease-associated” genes implicated in T1D, such as MHC class I and II loci, as well as non-MHC linked genes such as Ins, Ctla4, Il2, Il2ra, Il21, and Ptpn22[3]. Here, CTLA4 is linked to type 1 diabetes mellitus.