In addition to genes coding for lipases, Pnliprp1, Pnliprp2, Cel, and Pnlip, those encode peptidases such as Ctrl, Cpb1, Ctrb1, Prss2, Cpa2, and Cpa1 constitute the constellation of genes that may impact T1D pathogenesis. This evidence concerns the gene PRSS2 and type 1 diabetes mellitus.