Previously, we have shown that TSA treatment alleviated T1D in NOD mice and also up-regulated the expression of the transcription factor Tbx21/Tbet and Ifng genes without altering the levels of some of the genes implicated in diabetes such as Il4, Il17, Il18, and Tnfa in activated T lymphocytes [8]. This evidence concerns the gene TBX21 and type 1 diabetes mellitus.