In the present state of the art, the scenario for NTM diseases, with respect to TNF-blocking drugs, seems different from the TB counterpart: in particular, through extensive experimental screening, both Wallis and coworkers [10], and Winthrop and coworkers [23], [24] evidenced that latency and reactivation do not seem to play a crucial role in this context, yet a clear-cut picture is still missing. This evidence concerns the gene TNF and tuberculosis.