In order to investigate possible correlations between the incidence of infections by such Mycobacteria and biological therapy, one could rely directly on the molecular details of TNF processing signal (which has been, at least partially, elucidated, see e.g. [25]), coupled to the underlying infliximab and etanercept mechanism of action, which could be achievable directly through molecular immunology approach. The gene discussed is TNF; the disease is infection.