Additionally, the silencing suppressor activity of the TMV 126-kDa small replicase subunit is correlated with increased virus induced symptoms in tobacco [42] and it has been described that some phytoviruses RNA-silencing suppressors including the P38 protein of Turnip crinkle virus (TCV), the P19 protein of Tomato bushy stunt virus (TBSV) and the P15 protein of Peanut clump virus (PCV) were functional as silencing suppressors in human Hela cells [43] Furthermore, many human cancers appear to be induced by miRNA deregulation [44]. Here, NSG2 is linked to cancer.