TLR1 and tuberculosis: In support of this hypothesis, the TLRs are upregulated as a group in both melioidosis (TLR1, TLR2, TLR4, TLR5, TLR6, TLR8 and TLR10) and tuberculosis (TLR2, TLR4, TLR5, TLR6, TLR7, TLR8).