MKI67 and metastatic malignant neoplasm in the lymph nodes: Multivariate analysis showed that age, tumor size, histological grade, lymph node metastasis, molecular subtypes, and Ki67 distribution pattern related to postoperative distant metastasis (P = 0.001, 0.035, 0.001, 0.001, 0.001, and 0.001, respectively) (Table 2).