CREB was upregulated at protein level and binding of CREB to the promoter region of C/EBPβ containing the CREs was also enhanced as revealed by chromatin immunoprecipitation experiments (Figure 5B and 5C), suggesting that CREB-C/EBPβ pathway is activated in candidemia-induced emergency granulopoiesis. Here, CREB1 is linked to Candidemia.