CA2 and central nervous system cancer: Regarding Cas II-gly action mechanism, it has been demonstrated that interferes both the electron transfer chain and oxidative phosphorylation in mitochondria isolated from cardiac muscle [12] and glioma cells [6], and also affects mitochondrial ATP synthesis in rat AS-30D hepatocarcinoma and HeLa cells, two highly OxPhos-dependent tumors [46], by interacting with the reactive thiol groups of Krebs cycle (pyruvate, 2-OG, succinate) dehydrogenases [11]–[13].