IL18R1 and asthma: IL-18 inhibitors, including caspase-1 inhibitors, anti-human IL-18 monoclonal antibodies, anti-human IL-18R monoclonal antibodies, soluble IL-18 receptor complex [11] and/or IL-18 binding protein (BP) [37] may be clinically beneficial for the treatment of patients with steroid-resistant asthma, for whom current treatment options are very limited.