In the paper that investigated the role of fatty acid composition in the development of metabolic disorders in sucrose-induced obese rates, the different time courses of the increases in plasma glucose, insulin, and triglycerides during the course of developing obesity suggest that some time- or tissue-dependent process is necessary to induce these metabolic abnormalities [22]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.