To evaluate the potential role of Aβ peptides in pathological abnormalities related to NPC disease, we have recently developed a new line of bigenic ANPC mice by crossing heterozygous Npc1-deficient mice with mutant human APP transgenic (APP-Tg) mice which exhibit extracellular Aβ deposits and spatial learning deficits but no overt loss of neurons in any brain region. This evidence concerns the gene NPC1 and nasopharyngeal carcinoma.