Further adjustments for other potential confounding factors including age, gender, body mass index, prevalence of diabetes, the use of angiotensin-converting enzyme inhibitor or angiotensin receptor blocker drugs, 24-h mean systolic blood pressure, LVMI, LAVI, E/A, deceleration time, IVRT, lgNT-proBNP and lgUACR did not materially change the magnitudes of the associations (adjusted OR for group 3 vs. group 1: 8.31, 95% CI 2.00–34.56, p = 0.004). This evidence concerns the gene NPPB and diabetes mellitus.