RHOC and neoplasm: As revealed in Table 2, 30 cases showed relatively strong RhoC immunoreactivity in tumor tissues (++, 18 cases; +++, 12 cases), whereas only 15 of these subjects showed strong RhoC expression in adjacent normal liver tissues (++, 15 cases; +++, 0), suggesting that the enhanced RhoC expression might be related with the tumorigenesis of HCC.