In conclusion, the present study demonstrates on one hand the expression of AQP7 in human adipocyte plasma membrane and on the other hand the presence of an alternative glycerol channel, AQP10, that working with AQP3 and AQP7 ensures glycerol exit from adipocyte, thus protecting humans from obesity. Here, AQP10 is linked to obesity due to melanocortin 4 receptor deficiency.