CD4 and tuberculosis: Previous studies in countries of high TB prevalence [17], [18], had raised concerns about an increased rate of negative QFT but not T-SPOT.TB results in individuals with low CD4+ T-cell counts; however, a recent metanalysis called this into question [28] Our clinical cohort offered an opportunity to directly compare current commercial versions of the tests in an outpatient clinic in a low TB prevalence setting with individuals with a range of CD4+ T-cell counts.