AQP5 and Schwartz-Jampel syndrome: Studies indicate that different AQP5 staining methods on the salivary or lacrimal glands of SjS patients have produced inconsistent results; abnormal distribution/selective defect for AQP5 trafficking to apical membrane vs. no difference in the distribution and density of AQP5 in patients with primary SjS [20], [21], [22].