The in-cis genes included known cancer-associated genes such as ERBB2, MAP3K7, MDM4, FGFR1, CCND1 and FADD. Further annotation of the 578 genes showed that 19% code for enzymes, 8% regulators of transcription, 7% transporters, 4% kinases, 2% peptidases, and 2% phosphatases (Figure S3A). The gene discussed is MDM4; the disease is cancer.