USP22 and psychiatric disorder: The remaining disease-associated genes/loci are less well understood in psychiatric disorders, like FAM19A1, PLXNA4, LOC643308, RNU3P2, PALM2, SCARA5, RPS27AP4, and NPM1P3. The NAP1L1 and USP22 variants, for example, are cancer-related genes/loci and the gene, ALCAM (also called CD166) was originally identified as a transmembrane receptor that is involved in T-cell activation, development, inflammation and transendothelial migration of neutrophils, and a cancer susceptible gene [51].