This well-known capability of IFNα/β should significantly impact on cytokine biology since production of type I IFN is not merely upregulated by infections but also by inflammation in the context of autoimmunity and beyond that by more general means of cellular stress (Taniguchi and Takaoka, 2001; Kalliolias and Ivashkiv, 2010). The gene discussed is IFNA1; the disease is Autoimmunity.