TNF and major depressive disorder: Sig pos α between Δ IL-1β and Δ depression sxs (p = 0.04). For 16KKW not 4 KKW NS change in cytokine levels following 12 weeks of EXC. NS relationship between EXC dose and change in cytokine levelsHigh TNF-α may predict better outcomes with EXC vs. ADs↓ IL-1β α positive depression treatment outcomes