One Rnf8−/−p53−/− mouse in the survival cohort developed both a B-cell lymphoma (B220+IgM+) (Figure S8A) and a thymic lymphoma (CD4+CD8+) (Figure S8B), whereas the rest of the cohort developed thymic lymphomas exclusively (Figure S8C). This evidence concerns the gene CD40LG and B-cell non-Hodgkin lymphoma.