To examine the effect of dual loss Rnf8 and p53 on tumor development, we monitored cohorts of Rnf8−/−p53−/−mice and their Rnf8−/−  ̧ p53−/− and WT controls for one year, and Kaplan-Meier tumor free survival analysis was performed. The gene discussed is RNF8; the disease is neoplasm.