NIPBL and colorectal cancer: For example, identification of yeast CIN genes [11]) led to the sequencing of the human homologs of 200 yeast CIN genes in human colorectal cancers, and it was discovered that human homologs of the yeast CIN genes SMC1, SCC2, BUB1, PDS1, MRE11, and CDC4 collectively account for approximately 25% of the mutational spectrum of colorectal cancer [12]–[15].