Notably, for 4 of these loci, the GWAS hit was among, or in complete LD (r2 = 1) with one of the identified cis htSNPs: C1orf85 (locus for mean corpuscular hemoglobin concentrations [24]), IREB2 (locus for chronic obstructive pulmonary disease [25]), OPTN (locus for Paget's disease) [26]) and TSEN2 (locus for prostate cancer [27]). The gene discussed is IREB2; the disease is Paget disease.