If this were true, then pleiotropy between the effects of IKZF1 on SLE and on IgG N-glycans in human plasma, revealed by independent GWA studies, would lead to a discovery of a novel class of biomarkers of SLE – IgG N-glycans – which could possibly extend their usefulness in prediction of other autoimmune disorders, cancer and neuropsychiatric disorders, through the same mechanism. Here, IKZF1 is linked to autoimmune disease.