The amount of secreted chemokines MIP-2/CXCL2 and KC/CXCL1, which play key roles in the chemoattraction of neutrophils during experimental UTI [23], [26]–[28], was also significantly lower in kidneys from CsA-treated mice than vehicle-treated mice (Figure 1C). This evidence concerns the gene CXCL2 and bacterial urinary tract infection.