However, in our study, we did not find any positive evidence for a selective enrichment of HLA-G+ CD4 and CD8 Treg in lymphoid tissues, either in HAART-treated or in untreated HIV-1 patients; but this observation in a limited number of patients does not exclude the possibility of tissue compartmentalization of HLA-G+ Treg in HIV-1 infection. This evidence concerns the gene CD4 and HIV-1 infection.