Similar prion-like transmission has been demonstrated in various settings for other misfolded proteins involved in human neurodegenerative diseases, including the intracytoplasmic proteins tau, also involved in AD and various neurodegenerative diseases referred to as taopathies, and α-synuclein, the primary constituent of Lewy bodies found in Parkinson's disease [18]. This evidence concerns the gene MAPT and neurodegenerative disease.