MEG3 and Impaired glucose tolerance: In addition, individuals from Dutch hunger winter families also had lower DNA methylation of the imprinted INS-IGF2 (INSIGF) gene, but increased DNA methylation of the guanine nucleotide-binding protein (GNASAS), maternally expressed 3 (MEG3), interleukin-10 (IL10), ATP-binding cassette A1 (ABCA1), and leptin (LEP) genes in parallel with impaired glucose tolerance compared with their unexposed same-sex siblings [85].