We found that while control SW620-LacZ cells were able to express high levels of GLUT1 (∼75%) that clearly localized to the plasma membrane, SW620-hTRM9 tumour sections showed a marked decrease in GLUT1 expression (∼5%) that was irregularly distributed in a membrane-like pattern (Fig 5E). The gene discussed is SLC2A1; the disease is neoplasm.