RNA interference (RNAi) targeting SATB1 has been successfully used in sarcoma[15], leukemia[16] and pancreatic cells[17], few report has been published concerning the effect of small interfering RNA (siRNA) on the SATB1 gene in SCLC cells, in our study, we investigated the expression of SATB 1 and its role in the pathogenesis of SCLC by knocking down SATB1 in NCI-H446 cells. Here, SATB1 is linked to sarcoma.