We investigated more precise and accurate mechanisms with in vitro studies utilizing the IL-22 and IL-6 depletion assay; cell survival and tumor promotion was eliminated when IL-22 was blocked based upon the attenuated activation of STAT3 which is similar to IL-6, Moreover, the specialty of IL-22 effect through STAT3 signaling was verified by using STAT3 inhibitor WP1066. Here, IL22 is linked to neoplasm.