IL-22 existed in the peri-tumor or non-parenchymal tissues around the intestinal gland area in most CC tissues (71 positive in a total of 82 cases, 71/82) and UC tissues (31/40), whereas normal colon tissue samples were almost all negative (5/40) (Figure 1B), which indicated that IL-22 acted as a driver of inflammation based on previous reports in IBD patients [35]. This evidence concerns the gene IL22 and inflammatory bowel disease.