IL22 and malignant colon neoplasm: Recently, the rs1179251 SNP in IL-22 was demonstrated to be associated with risk of colon cancer [29]; Nagakawa et al. demonstrated that IL-22 does not directly act on immunocompetent cells, and artificially IL-22 expression in CC cell line can favor apothanasia of inoculated hosts [30]; An additional two studies were conducted to investigate the role of IL-22 in UC that revealed that IL-22 played a pivotal role in UC pathophysiology through both DMBT1 and REGα [31,32].