IL22 and neoplasm: Significant increase in tumor volume was evident when Hct-116 cells were co-transplanted with TILs compared to Hct-116 cells alone; moreover, our findings indicated that elevated IL-22 expression was correlated to enhanced tumor volume (TILs1, 1.63 ± 0.23 cm3 vs. Hct-116, 0.34 ± 0.19 cm3, P = 0.0019, P < 0.01; TILs2, 2.01 ± 0.30 cm3 vs. Hct-116, P = 0.0048, P < 0.01, TILs1 vs. TILs2, P = 0.022, P < 0.05 by unpaired t-test; Figure 4B1 and B2).