In 2005 it was shown that IL-22 was much higher in UC compared to CD, and a study of human IBD revealed that IL-22 derived from activated T cells acts on human colonic subepithelial myofibroblasts to stimulate secretion of proinflammatory cytokines and matrix-degrading molecules, thus demonstrating its proinflammatory/remodeling role in IBD [35]. Here, IL22 is linked to inflammatory bowel disease.