This enrichment yielded a number of drugs that are known drugs for the treatment of diabetes such as ‘rosiglitazone’, ‘metformin’ , ‘pioglitazone’, and also ‘glucagon’ and ‘insulin’ which are frequently used for the treatment of hypoglycemia and hypoinsulinemia (Table2A. For the full list see Additional file2: Table S4A). Here, INS is linked to diabetes mellitus.