MTDH and migraine disorder: More recently, GWAS have identified several single nucleotide polymorphisms linked to migraine pathophysiology [48-50] in genes or in regulatory regions of genes involved in epigenetic processes, including MTDH, MEF2D and PRDM16. For example, metadherin (MTDH) associates with nuclear factor κB (NFκB) and a HAT to promote the expression of NFκB target genes [51].