CRB1 and Leber congenital amaurosis: The prevalence of CRB1 mutations varies widely depending on the clinical phenotype and the cohort studied, ranging between 7% in EORD patients [6], 10% in LCA patients [7], 31% in RP patients with Coats-like exudative vasculopathy and 66% in RP patients with PPRPE [8].